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The clinical presentation can vary widely depending on the type of mutation affecting SLC22A5 and the phenotypic manifestation of the mutation, i.e., age of onset, organ involvement, and severity of symptoms at the time of diagnosis (34)
According to Valentini et al., acupuncture therapy may enhance microcirculation in patients suffering from peripheral artery disease (PAD) and diabetic foot syndrome (DFS) (125)
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