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Massive intoxication De onderhoudsdosis van bag 2 wordt verhoogd indien er sprake is van een zogenaamde massale intoxicatie, dit is in een minderheid van de patinten het geval
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On the other hand, mTORC2 is linked to cell survival and actin organization (Takahara et al., 2020)
Inhibition is characterized by the elimination of the back-and-forth WAT1 and Gln143 proton transfer that is central for PCET catalysis 27,67 , where dioxygen species replacing the WAT1 position is a result of favored molecular orbital overlap with the Mn 3d z 2 orbital
