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Unlike the global D3KO mouse, in which developmental loss of D3 in the skin results in impaired clearance of TH thereby leading to elevated levels of TH action that reduce neonatal viability, growth retardation and central hypothyroidism [66], epidermal-specific D3 depletion after birth does not alter systemic THs or TSH levels [40]

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Although Compounds 1.62 and 1.63 lost the efficacy for a major detoxification process of GSH by being unable to interact with the GST enzyme, this does not indicate a loss for all the detoxification pathways

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