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Of note, while we cannot completely exclude effects by parkin deficiency on de novo glutathione synthesis, we found no significant rise in mRNA levels of subunits for the rate-limiting enzyme, i.e., glutamate-cysteine ligase ( Gclm and Gclc ), nor did we see a consistent rise in total glutathione (GSH + 2GSSG) concentrations across the parkin-deficient-only model systems

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Growth hormone insensitivity syndrome: therapy for 6.57.5 years with recombinant insulin-like growth factor I in children with growth hormone insensitivity syndrome: a clinical research center study