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Prolonged cAMP signaling and homologous desensitization Intuitively, reduced loss of surface GLP-1R with exendin-phe1 should permit greater access to extracellular ligand during continuous exposure, with fast recycling ensuring that the receptors are maintained in a sensitized state
(4) ongoing telehealth follow-up supports dose titration and side-effect management
In some patients, this temporarily raises uric acid and can trigger a gout flare in the first few months
These assessments ensure that beneficial metabolic effects persist and no adverse metabolic changes emerge
