can you get off glp 1 GLP-1 drugs without gaining weight TrimRX | How to Taper

The test reveals these predispositions in peptide and metabolic pathways, supporting more personalized conversations with your provider about titration strategy and monitoring expectations

The Numbers That Matter: In the landmark SURMOUNT-5 trial published in the New England Journal of Medicine in May 2025, participants taking tirzepatide lost an average of 20.2% of their body weight over 72 weeks, compared to 13.7% with semaglutide

On average, those using both lost 17% of their body weight, compared to 14% for those using tirzepatide alone

However, if you are also taking sulfonylureas or insulin, adding even a microdose of tirzepatide could push blood glucose too low