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This closure causes membrane depolarization, which opens voltage-dependent calcium channels

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While some studies found no difference between individuals with T2DM and matched non-diabetic controls (6769), others found plasma DPP-4 activity to be reduced in the patients, and suggested this might reflect a compensatory response to the reduced insulin sensitivity and hyperglycaemia, in an attempt to increase intact incretin hormone concentrations and improve insulin secretion (70, 71)

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Do not use if you are pregnant, may become pregnant, or are breastfeeding

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