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Interpreted with qualified provider guidance, this information can support earlier identification of patients likely to benefit from combination therapy or need dose adjustments

Cimetidine In a study assessing disposition of sertraline hydrochloride (100 mg) on the second of 8 days of cimetidine administration (800 mg daily), there were increases in sertraline hydrochloride mean AUC (50%), Cmax (24%) and half-life (26%) compared to the placebo group [See Drug Interactions (7.2)]

The effect of this stimulation is more potent when GIP is co-administered [51]