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semaglutide alzheimer trial evoke and evoke+: design of two large‐scale, double‐blind, placebo‐controlled, phase 3 studies evaluating the neuroprotective effects of in early Alzheimer's disease - Atri - 2022 - Alzheimer's & Dementia Blockbuster GLP-1 Diabetes and Weight
Description
Semaglutide can cause muscle loss if not managed
Several RCTs showed the efficacy and tolerability of semaglutide for the treatment of obesity
Rubino, F
The incorporation of a 104-week treatment period and 52-week extension, resulting in a total treatment period of 156 weeks in evoke/evoke+, allows for a comprehensive evaluation of the time to dementia progression in participants with baseline MCI, as well as long-term efficacy
