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Future drugs may be designed to target the reward circuit while skipping the nausea circuit
The leptin-melanocortin axis, the opioid system, glucagon-like peptide-1 (GLP-1)/glucagon-like peptide-1 receptor (GLP-1R) system, and fibroblast growth factor 21 (FGF21)/its receptor complex FGFR1c/-klotho axis are several common pathways confirmed by researches and pharmacological targets that play an essential role in regulating energy balance and feeding behavior (2)
Clinically, a majority of T2DM cases are due to obesity
Reprod Biomed Online 2019
