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Description
Other GLP-1R/GIPR co-agonists such as Cpd86 (Eli Lilly), ZP-DI-70 (Zealand) and NN9709/MAR709 (Novo Nordisk/Marcadia) have also been designed and tested in preclinical models of obesity and subsequently advanced to clinical trials (Table 1)

This was known as the TRIUMPH-1 trial and evaluated 2,339 participants over 80 to 104 weeks

Peripherally, GLP-1R enhances glucose control by increasing insulin secretion and reducing glucagon production, delays gastric emptying and regulates intestinal hormones

When reconstituted with bacteriostatic water and stored properly under refrigerated conditions (typically 2-8C), most peptides remain stable for several weeks
