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Thats a subtle but important shift in how we understand these medications

Temporary nausea, constipation, or mild digestive issues are common early on but usually improve with time

Patients with lower GLP1R activation potential may see faster results with higher baseline doses, while others benefit from a gradual titration strategy

Rough estimates based on the number needed to treat suggest tirzepatide is superior to resmetirom in both MASH regression and fibrosis improvement (1.9 vs