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The most common side effects are nausea, reduced appetite, constipation and fatigue, usually around dose increases

However, a correlation was found between treatment duration and weight loss, indicating that a longer treatment duration was associated with higher weight loss (slope P=0.02

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In addition to the two primary uses for retatrutide, Lilly said it is evaluating the drug's potential for a host of obesity-related medical conditions, including knee osteoarthritis, moderate-to-severe obstructive sleep apnea, chronic low back pain, cardiovascular and renal issues, and metabolic dysfunction-associated steatotic liver disease