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Pseudo-islets generated from FACS-purified CD63 high cells had increased GSIS, enhanced mitochondrial activity, and restored glycemia when transplanted in NOD SCID diabetic mice compared to CD63 low-expressing pseudo-islets (Rubio-Navarro et al., 2023)
Despite these advances, KRAS inhibitors like sotorasib face resistance mechanisms primarily through the activation of bypass pathways such as autophagy and PI3K-AKT signaling
10.1016/j.bcp.2020.114172 58 ImJ.HergertP.NhoR
