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Severe Illness Inpatient and outpatient management of COVID-19 is complicated by its widely variable clinical course

4.3 The vicious cycle of metabolic deficits and immune activation Mitochondrial dysfunction may result in overproduction of ROS and the release of mtDNA, both of which serve as DAMPs, activating the NLRP3 inflammasome in both peripheral and central immune systems, thereby promoting the release of pro-inflammatory cytokines, such as IL-1 and IL-18 (168170)

This direction is particularly relevant to the field of sports medicine, where exercise-induced metabolic adaptations could potentiate the hepatoprotective effects of plant-derived compounds

While these stories sound convincing, the peptide has not passed all required human clinical testing yet