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Molecular Mechanisms of Vitamin E Signaling in the Retina Vitamin E is known to activate kinases and transcription factors that regulate gene expression (Figure 1)

FIGURE 4 The slr0236 , sll1545 , and slr0236-sll1545 Mutants Exposed to Methylene Blue Undergo a Transient Sequential Accumulation of ROS, and Then of Reduced and Oxidized Glutathione The effects of methylene blue on the content of ROS and glutathione were similar but lower in amplitude than those triggered by the high-light stress (Figure 5), in agreement with the fact that singlet oxygens generated by MB ( per se by the ROS-detecting DCHF-DA probe (Figure 5B)

Because HoloTC is the most specific and most sensitive laboratory biomarker for the detection of B 12 deficiency, HoloTC should be used for screening