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377 In AD mice, injection of BM-MSC-EVs reduced plaque deposition and brain A levels, decreased the activation of astrocytes and microglia, downregulated pro-inflammatory cytokines (TNF- and IL-1), and upregulated anti-inflammatory cytokines (IL-4 and IL-10)

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The importance of epigenetic regulations in the memory process has been highlighted [27] through the involvement of small regulatory RNAs, DNA methylation and histone modifications (proteins structuring DNA within chromatin)