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In humans, a transactivation domain, which has been shown to enhance transcriptional activity, is kept inactive by a regulatory domain located between HR-A/B and HR-C domains [71,72]
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For example, through inhibition of mitochondrial complex I, biguanides disrupt the electron transport chain and subsequently affect cellular energy metabolism [2224]
( a ) Spatial location of AT1G72290 , AT2G34930 , and BBM transcripts in three-day-old etiolated seedlings of (left) Col-0 and (right) hls1
