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Since NAMPT, in the rate-limiting reaction of NAD + salvage pathway, consumes NAM, which acts as an endogenous inhibitor of SIRT1, to regenerate and boost NAD + pool, thus promoting SIRT1 activation
Glutathione is a harm reduction tool for occasional use, not a hepatoprotective strategy for regular drinking
Nonetheless, it is conceivable that ALA would exhibit nephroprotective effects in IgAN, given its powerful antioxidant capacity
