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Description
This review, will focus on the vital components that make up the BBB, dissect levels of disruption of the barrier, and discuss current drugs and therapeutics that maintain barrier integrity and the recent discoveries of effects microbial-derived metabolites have on BBB physiology.

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Very recent study found significant improvement of behavioral deficits including cognitive decline, depressive-like behaviors, in APP (NLG-F/NLG-FG-) mice due to oral GSH administration
