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Ramos-Tovar E, Muriel P (2023) NLRP3 inflammasome in hepatic diseases: a pharmacological target

Arginine metabolic regulators such as spermidine have been shown to suppress M1 macrophage-associated cytokines while inducing M2 macrophage-related markers, significantly alleviating EAE symptoms, whereas Arg1 inhibitors can reverse these effects ( In other autoimmune diseases, amino acid metabolic reprogramming likewise participates in the formation of the inflammatory microenvironment by regulating macrophage polarization

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Glutathione is a tripeptide (cysteine, glycine, and glutamic acid) present in high levels in most cells, which exists in two forms, reduced (GSH) and oxidized (GSSG)