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Description
In addition, the analgesic effect of melatonin is mediated through activation of supraspinal sites, inhibition of spinal nociception, and modulation of various neurobiological systems, including GABAergic, opioid, and glutamatergic systems [65]
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By suppressing the expression of the nuclear factor kappa B (NF-kB) gene, CoQ10 may have anti-inflammatory properties by lowering the synthesis of interleukin 1 (IL-1), IL-6, and tumor necrosis factor (TNF- ) gene expression [19]
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