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Epigenetic mechanisms in diabetic vascular complications

In patients with severe liver disease, portal blood bypassing the liver leads to increased levels of ammonia and other toxic substances in the blood, which can lead to complications such as brain damage, sarcopenia and muscle spasticity [204]

Another single-blind trial in which 124 subjects with mild to moderate acne were randomly assigned to either 5% topical tea tree oil gel or 5% benzoyl peroxide showed that both formulations significantly reduced total lesion count, and the tea tree formulation caused slightly fewer side effects (Bassett 1990)

However, better delineation of the therapeutic and prophylactic roles of L-carnitine in these conditions will require further investigations in controlled, randomized and probably multicentre trials to evaluate the clinical value and the appropriate dosage of L-carnitine in each of these conditions