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This substantial body of research examined the peptide across numerous systems: gastrointestinal healing, musculoskeletal repair, cardiovascular function, neurological protection, and immunomodulation

In this review, we will focus on the metabolic effects of IGF-1, the concept of metabolic syndrome and its clinical manifestations (impaired lipid profile, insulin resistance, increased glucose levels, obesity, and cardiovascular disease), discussing whether IGF-1 replacement therapy could be a beneficial strategy for these patients

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In general, metoclopramide and domperidone were equally effective for relief of symptoms, although central nervous system adverse effects were more common with metoclopramide (Patterson et al., 1999