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The questionnaire included 10 items: irritability, tremors, anxiety, palpitations, mood lability, insomnia, impaired concentration, exertion dyspnea, excessive sweating, and heat intolerance

Chorismate mutase, also known as hydroxyphenylpyruvate synthase or chorismate pyruvatemutase, is the isomerase enzyme involved and catalyzes the committed step of phenylalanine and tyrosine, namely the formation of prephenate

Patients present either shortly after birth with acute deterioration, metabolic acidosis and hyperammonemia or later at any age with a more heterogeneous clinical picture, leading to early death or to severe neurological handicap in many survivors

Potent inhibition of VEGFR-2 activation by tight binding of green tea epigallocatechin gallate and apple procyanidins to VEGF: relevance to angiogenesis