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Am J Physiol Gastrointest Liver Physiol

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The molecule has become the canonical chemical probe for the entire NNMTmethylationNAD axis and is the foundation for a growing field of methylation-rejuvenation research

Originally developed by NeuroSearch as a treatment for neurodegenerative diseases (Parkinsons and Alzheimers), tesofensine was found during clinical trials to produce significant body weight changes as a side effect, redirecting its development toward metabolic research