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Moreover, in the first four weeks of supplementation with coenzyme Q10, a decreased severity of headache in patients with episodic migraine was observed

Results from the biological evaluation, the acylamino compounds ( 31a 31g , Figure 11) exhibited potent tyrosinase inhibitors than kojic acid (IC 50 = 28.5 M), and in contrast, the aminophenones ( 31 h and 31i ) showed activation of tyrosinase activity

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Establishing the dose of Co Q10 has been a topic of discussion
