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HCN1 channels were proposed as a new drug target in CIPN, and HCN1-selective inhibitors might be a new class of medications for CIPN [155]

FIGURE 1 Synthesis of glutathione takes place in two adenosine triphosphate (ATP)-depending steps and is highly compartment specific as the enzymes that trigger glutathione synthesis are encoded by single genes which are targeted to either chloroplast and/or the cytosol

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