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In a mouse model of hepatocellular carcinoma induced by diethylnitrosamine (DEN), liver GCN5L1 knockout increased DEN sensitivity in the model
Moreover, cancer-associated fibroblasts secrete microRNA-522 through the exosome pathway, which inhibits cancer cell ferroptosis by targeting ALOX15 and inhibiting the accumulation of lipid-ROS

NAD acts as a central coenzyme in metabolic reactions that convert nutrients into ATP

These promising results led us to investigate the mechanism of GliSODin
