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They work synergistically through different mechanisms, with combined administration producing approximately five times greater GH release than either compound alone

Future studies employing chromatin immunoprecipitation assays will be necessary to definitively test whether HIF-1 and/or c-Myc directly bind to the SLC16A1 promoter in SCs and how this is governed by SYK activity

Hampel H, Frankel WL, Martin E, Arnold M, Khanduja K, Kuebler P, et al

Luo et al., 2025)
