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The body needs time to reach new steady-state plasma levels at each tier, which is precisely why escalation schedules space increases four weeks apart at minimum
Although the BB-50 brush-border antigen was also localized in peritubular capillaries (Mutti et al., 1985), subsequent work lead to the identification of a monoclonal antibody reacting with an antigen located specifically in the brush border and thus called BBA or brush-border antigen (Mutti et al., 1988)
For this purpose, we utilized a son of sevenless (SOS)-catalyzed nucleotide exchange assay
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