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severe hypoglycemia occurred in 0.8% and 1.2% of patients when semaglutide 0.5 mg and 1 mg, respectively, was given with a sulfonylurea

The recent published work by Nordahl et al on an AAV-driven ET-1 overexpression model that was similar to the one used in our study found retinal damage using ERG (Nordahl et al, 2023)

doi: 10.3390/cells9091982

Therefore, part of the increased energy intake observed in the luteal phase may represent a compensatory physiological response to elevated metabolic demands rather than purely hedonic overconsumption
