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Using genetic engineering, dendritic cells (DCs) have been engineered to secrete exosomes expressing Lamp2, an exosomal membrane protein, fused with the neuron-specific RVG peptide (YTIWMPENPRPGTPCDIFTNSRGKRASNG) 35

Alternative forms like liposomal and intravenous delivery methods are considered to enhance bioavailability and efficacy in increasing systemic glutathione levels

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All of these are proteins involved in RNA processing: (a) associated components of the U1-snRNP and SMN complexes, (b) known splicing factors (SFSR1 and SFSR3), (c) other ALS-linked RBPs (EWSR1, TAF-15 and TDP-43), (d) associated with polyadenylation (CPSF-160 (cleavage and polyadenylation-specific factor 1, 160 kDa) and PABPC1 (cytoplasmic poly(A)-binding protein 1)) and (e) components of the Drosha microprocessing complex (DDX3, DDX5, DDX17 and hnRNP-U1-like protein) essential for microRNA biogenesis