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Studies have found a decrease in antioxidant levels and an increase in oxidative damage products in patients with MDD, and have shown a positive correlation with the severity of the disease and the increased number of depressive episodes

These changes shift microbial metabolism toward greater short-chain fatty acid (SCFA) production, particularly butyrate, which supports epithelial energy metabolism, reinforces barrier function, and epigenetically regulates T-cell differentiation (Van Deuren et al., 2022)

The intersection target data were imported into the DAVID database, 17 and GO and KEGG enrichment analyses (Chen J

2), indicating general growth-promoting effects in addition to stress mitigation