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Description
Across roughly six trials in more than 900 participants, an early shorter study suggested a promising signal, but the pivotal 24-week randomized, double-blind, placebo-controlled trial (METAOD006) did not reach statistical significance versus placebo, and the peptide added no benefit over an intensive diet-and-exercise regimen

doi:10.1038/ejcn.2014.165

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Annu Rev Immunol
