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Interestingly, hyperoxia enhances GPx-1 transcription in human umbilical-vein endothelial cells through a mechanism independent of the ORE (190), suggesting that GPx-1 transcription may be regulated in response to oxygen tension by more than one mechanism

Contact a healthcare provider if you notice: Persistent or worsening neuropathy symptoms, such as tingling, numbness, burning pain, or weakness New or unusual side effects, including skin rash, itching, or acne-like breakouts Possible medication interactions, especially if you take metformin, acid-reducing medications, or other long-term prescriptions Changes in neurological function, such as balance issues, confusion, memory changes, or worsening coordination Recognizing these warning signs early helps prevent complications and supports better long-term nerve health outcomes

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More studies are needed to confirm these results