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doi: 10.1038/ncomms3935

(7) Complex II: Complex II (succinate dehydrogenase, SDH) is an FAD-dependent enzyme embedded in the mitochondrial inner membrane that oxidizes succinate to fumarate as part of the TCA cycle while transferring the resulting electrons through FAD and a series of ironsulfur clusters to ubiquinone (CoQ 10 ), reducing it to ubiquinol (CoQ 10 H 2 ) 74

In addition to inducing irreversible oxidative modification of proteins (protein oxidation and peroxidation), lipids, and glycans (advanced lipoxidation and glycation end products), excessive ROS not only causes genomic mutations but also promotes disease or cell death when unchecked by protective antioxidant systems

Hydrogen peroxide toxicity in human thyroid cells