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When a big company takes over a little company, they pick out the bits that they think fit what they want, and leave the rest, said Michael Parnham, who was a senior scientific adviser at PLIVA at the time of the acquisition by GSK

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For example, anti-transferrin receptor (TfR) BACE1 bsAbs leverage TfR-mediated transcytosis to deliver therapeutic antibodies across the blood-brain barrier, thereby reducing -amyloid (A) accumulation in the treatment of Alzheimers disease [243]

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This does not mean the data is wrong, but it does mean it carries less weight in the global evidence hierarchy

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