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also reported that GRK2 expression is increased in blood lymphocytes of hypertensive patients and the impaired -AR-mediated vasorelaxation in the brachial artery is restored by treatment with heparin, a nonspecific GRK inhibitor [66]

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That is the reason it is considered relatively safe even at high doses

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BROND sets this expectation so customers understand results vary and are supported by provider-guided dosing rather than quick, one-size-fits-all promises

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