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A small, short-term single blind study showed that administration of an antioxidant mixture (N-acetylcysteine, vitamin E, and vitamin C) to control subjects, as well as subjects with type 2 diabetes and impaired glucose tolerance reduced the increase in oxidants and endothelial markers evoked by a fatty meal [41]

doi: 10.1523/JNEUROSCI.4778-07.2008

Meanwhile, dose change of sorafenib was in correlation with the occurrence of adverse events (141), so the combination of sorafenib with chemotherapy drugs should be further explored in large-scale cohort studies

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