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Tumour angiogenesis, the formation of new vasculature to supply nutrition and oxygen in a direction from pre-existing blood vessels toward tumours, is prerequisite for tumour progression (4)

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MET may lead to chemoresistance through stimulating epithelial-mesenchymal transition The process of epithelial-mesenchymal transition (EMT) enables cells to invade surrounding tissues and metastasise, with enhanced migratory capacity, invasiveness, production of extracellular matrix components and resistance to apoptosis [74, 75]
