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Perlmutter has published papers in peer reviewed journals including the Journal of the American Academy of Dermatology and the Journal of the American Medical Association

This review emphasizes that amino acid metabolism is not an isolated regulatory module, but rather part of an interconnected network that, together with glycolysis, the pentose phosphate pathway, tricarboxylic acid cycle anaplerosis, one-carbon metabolism, and lipid metabolism, determines macrophage fate

Additionally, its efficacy is limited in cancer cells with low ACSL4 expression, such as luminal subtype breast cancer (151)

Notably, complete depletion of each these genes in mice causes embryonic lethality 22,24,25