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The authors could not provide data on the mechanism by which zinc affects vitamin E metabolism and/or function but hypothesized that zinc may affect the bioavailability of vitamin E: the deficiency of zinc may cause oxidative stress and depletion of the available vitamin E because it is oxidized in the process of combating peroxyl radicals
NHK is encoded by a frameshift mutation of 1AT that results in a truncated and terminally misfolded product that is retained in the ER and undergoes ERAD
doi: 10.3168/jds.S0022-0302(01)74617-2 43
Most studies investigating the relevance of RET in human pathology have been focused on the tissue damage occurring during ischaemia/reperfusion in heart attack and stroke
