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Individual protocols vary significantly
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The stakes are high: improper solvent choice, aggressive mixing, or incorrect concentration calculations can permanently degrade peptide structure before a single dose is delivered
Electron microscopic analysis has shown that 48 h after LPS treatment, the glycocalyx of glomerular endothelial cells and podocytes begins to disappear, and endothelial fenestrations are lost or edematous, such that a gap forms between the podocytes and the basement membrane (15)
