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Furthermore, the therapeutic implications of SAMe are promising, with evidence suggesting that SAMe supplementation or modulation could improve the efficacy of existing cancer treatments by restoring proper methylation patterns and mitigating oxidative damage and protect against damage induced by chemotherapeutic drugs

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Lipid peroxidation products like HNE and 15d-PGJ 2 also induce GCLM although the signaling pathways appear to differ with pathological levels of HNE (Iles and Liu, 2005)

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