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doi: 10.1016/j.mce.2020.111073 100 BernieriTRodriguesDBarbosaIRArdenghiPGBasso da SilvaL

J Biol Chem 283: 36283638

Lactate buildup at the site of chronic inflammation promotes disease by inducing CD4(+) T cell metabolic rewiring

This fits with earlier in vitro studies showing that 11,12-EET and also other EETs induces more robust tube formation and markedly increased vascular endothelial growth factor (VEGF)-A 74 and basic fibroblast growth factor (bFGF) expression in hypoxia and normoxia, 142 indicating that CYP2J2 in endothelium also contributed to cardioprotection