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As mentioned, formation of the ternary complex also governs the circulating levels of IGFBP-3 which under physiological conditions is present in a 1:1 molar relationship with IGF-I plus IGF-II

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UV light catalyzes copper ion oxidation, breaking the peptide-copper coordination bond that gives GHK-Cu its biological activity

doi: 10.1155/2011/179674
