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10.1111/j.1365-313X.2011.04861.x Plant J
When comparing proximal to distal ends of these bones, the faster-growing sites are located at the proximal humerus (shoulder), distal radius and ulna (wrist), and distal femur and proximal tibia (knee) [1,8,2127]

doi: 10.1111/eip.13149 121 NieL

In addition, adiponectin knockout decreases glucose tolerance which is associated with insulin hyposecretion in mice liver 115