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In experimental studies, AOD-9604 has been observed to stimulate fat oxidation , increase energy expenditure , and reduce adipose tissue accumulation through activation of beta-adrenergic lipolytic pathways

This peroxidase activity is mediated by a reduced cysteine residue (also referred to as peroxidatic Cys) that donates its electron to neutralize peroxide and then recycle back into its native form with the help of reductants like thioredoxin (Prdx1-5) and glutathione (Prdx6)

Environ Biotechnol 4(1):714 Dearfield KL, Auletta AE, Cimino MC et al (1991) Considerations in the U.S

It is likely that zonulin release is initiated by dysbiosis and gliadin by a similar mechanism