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In rats drinking daily for three months, BPC-157 reversed portal hypertension, hepatocyte enlargement, and fatty liver changes (Prkacin et al., 2001)

van Oosterhout, J

Access this article Similar content being viewed by others Abbreviations Drp1: dynamin-related protein 1 GFP: green fluorescent protein ROS: reactive oxygen species OXPHOS: oxidative phosphorylation NMDA: N -methyl-d-aspartate MD: middle domain GED: GTPase effector domain VD: variable domain SUMO: small ubiquitin-like modifier S: serine DNM1L: dynamin-1-like protein CCI: chronic constrictive injury ddC: 2,3-dideoxycytidine DRG: dorsal root ganglia Mff: mitochondria fission factor Fis1: fission protein 1 PKA: protein kinase A Ref-1: redox-factor 1 NOX4: type 4 isoform O-GlcNAcylation: O-linked - N -acetylglucosaminylation CDK1: cyclin-dependent kinase 1 NOS: nitric oxide synthase mPTP: mitochondrial permeability transition pore SOD: superoxide dismutase GSH: glutathione Mdivi-1: mitochondrial division inhibitor ODN: oligodeoxynucleotide HBO: hyperbaric oxygen pAMPK: phosphorylated AMP activated protein kinase CaMKK: calmodulin-dependent protein kinase kinase BHB: -hydroxybutyrate KD: ketogenic diet References Amiri M, Hollenbeck PJ (2008) Mitochondrial biogenesis in the axons of vertebrate peripheral neurons

In vivo, its metabolites include trichloroacetic acid, proving that it functions as a substrate (Poon et al., 2000) there by being capable of inhibiting the metabolism of other aldehydic substrates of ALDHs